It's still possible to play the game inasmuch as you can still control your character, but meaningful forward progress is no longer possible for whatever reason. One specific class of video-game glitches and/or design errors, however, is despised more than most: the ones that render the game impossible to win, thus forcing the player to start over from their last save, the beginning of the level, or even the beginning of the game.
Bugs can take a variety of forms: some as mundane as causing slowdown, others as catastrophic as a system crash, and others simply being pretty hilarious. As computer programs and video games have increased in size and complexity over the years, it's only natural that the number of bugs, glitches, and design errors has likewise increased.